Table 4.
Odds Ratio of Genotypes and Phenotypes
| SNPs | Genotype | 0 Symptoms | 1-7 Symptoms |
>7 Symptoms |
p value |
OR (95% CI) |
OR (95% CI) |
|
|---|---|---|---|---|---|---|---|---|
| 4-8 Weeks Post-Surgery |
n; % | n; % | n; % | 1-7 vs 7+ Symptoms |
||||
| IL1-a rs17561 |
GG | 1/2; 50.0% | 40/64; 62.5% |
38/55; 69.1% |
0.045 | -----a | 1.00 | |
| GT | 0/2; 0.0% | 22/64; 34.4% |
11/55; 20.0% |
-----a | 0.53 (0.20, 1.32) |
|||
| TT | 1/2; 50.0% | 2/64; 3.1% |
6/55; 19.9% |
-----a | 3.16 (0.52, 33.44) |
|||
| 12 Months Post-Surgery |
0 vs 1-7 Symptoms |
1-7 vs 7+ Symptoms |
||||||
| IL1-a rs17561 |
GG | 7/14; 50.0% | 47/74; 63.5% |
25/33; 75.8% |
0.050 | 1.00 | 1.00 | |
| GT | 5/14; 25.7% | 24/74; 32.4% |
4/33; 12.1% |
0.71 (0.17, 3.19) |
0.31 (0.07, 1.07) |
|||
| TT | 2/14; 14.3% | 3/74; 4.1% |
4/33; 12.1% |
0.22 (0.02, 3.23) |
2.51 (0.39, 18.25) |
|||
| SNPs | Genotype | No Limb Mobility (< 2 Symptoms) |
Limb Mobility (2+ Symptoms) |
p-value | OR (95% CI) |
|---|---|---|---|---|---|
| 4-8 Weeks Post-Surgery |
n; % | n; % | |||
| IL4 rs2070874 |
CC | 21/52; 40.4% | 33/68; 48.5% | 0.022 | 1.00 |
| TC | 28/52; 53.8% | 22/68; 32.4% | 0.50 (0.21, 1.17) | ||
| TT | 3/52; 5.8% | 13/68; 19.1% | 2.76 (0.64, 16.65) | ||
| SNPs | Genotype |
No Fluid Accumulation (< 2 Symptoms) |
Fluid Accumulation (2+ Symptoms) |
p-value | OR (95% CI) |
| 4-8 Weeks Post-Surgery |
n; % | n; % | |||
| IL6 rs1800795 |
GG | 42/54; 77.8% | 22/65; 33.8% | 0.025 | 1.00 |
| CG | 7/54; 13.0% | 40/65; 61.5% | 3.30 (1.18, 10.08) | ||
| CC | 5/54; 9.3% | 3/65; 4.6% | 0.63 (0.09, 3.50) | ||
| IL4 rs2070874 |
CC | 21/54; 38.9% | 54/66; 50.0% | 0.007 | 1.00 |
| TC | 30/54; 55.6% | 20/66; 30.3% | 0.42 (0.18, 1.00) | ||
| TT | 3/54; 5.6% | 13/66; 19.7% | 2.76 (0.64, 16.65) | ||
| IL4 rs2243250 |
CC | 19/55; 34.5% | 26/65; 40.0% | 0.033 | 1.00 |
| TC | 30/55; 54.5% | 22/65; 33.8% | 0.54 (0.22, 1.30) | ||
| TT | 6/55; 10.9% | 17/65; 26.2% | 2.07 (0.62, 7.59) | ||
| SNPs | Genotype |
No Discomfort (< 2 Symptoms) |
Discomfort (2+ Symptoms) |
p-value | OR (95% CI) |
| 4-8 Weeks Post-Surgery |
n; % | n; % | |||
| VEGF-C rs3775203 |
CC | 13/17; 76.5% | 35/93; 37.6% | 0.012 | 1.00 |
| AC | 3/17; 17.6% | 38/93; 40.9% | 4.70 (1.14, 27.44) | ||
| AA | 1/17; 5.9% | 20/93; 21.5% | 7.43 (0.95, 331.15) | ||
| 12 Months Post-surgery |
|||||
| IL13 rs1800925 |
CC | 40/73; 54.8% | 14/45; 31.1% | 0.007 | 1.00 |
| TC | 28/73; 38.4% | 20/45; 44.4% | 2.04 (0.82, 5.15) | ||
| TT | 5/73; 6.8% | 11/45; 24.4% | 6.29 (1.62, 26.61) |
a
Due to the small sample size for 0 symptom.