Skip to main content
. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: Cancer. 2016 May 31;122(18):2828–2835. doi: 10.1002/cncr.30082

Figure 2. Distribution of FBXW7 and POLE mutations in combined CRC cohorts.

Figure 2

Lollipop plots depict the number and location of somatic coding mutations in these two genes. Note that patients may have more than one mutation. Color indicates functional consequence of mutation: truncating (nonsense, frameshifting, splicing) (red) and missense (green). In both cohorts, FBXW7 mutations are spread throughout the protein and are enriched for truncating mutations, a typical pattern for tumor suppressor genes. The grey box overlapping POLE indicates the NCBI defined exonuclease domain used to define proofreading mutations. Younger patients have enrichment of mutations in the proofreading domain of POLE as compared to older patients.