Table 3.

Comparison of PPV and NPV of cervical and urine HR-HPV for detection of histology- confirmed CIN 2 and CIN 3 lesions

Lesion status	Specimen	Number of specimens					PPVg (95% CI)	NPVh (95% CI)
		Count	Disease present		Disease absent
			TPc	FNd	FPe	TNf
CIN 2a	Cervical	468	56	16	231	165	19.5 (15.1–24.6)	91.2 (86.0–94.9)
	Urine	468	55	17	189	207	22.5 (17.5–28.3)	92.4 (88.1–95.5)
CIN 3b	Cervical	430	29	5	231	165	11.2 (7.6–15.6)	97.1 (93.3–99.0)
	Urine	430	25	9	189	207	11.7 (7.7–16.8)	95.8 (92.2–98.1)

^aCIN 2 vs ≤ CIN 1 (excluded CIN 3)

^bCIN 3 vs ≤ CIN 1 (excluded CIN 2)

^cTP-True positive

^dFN-False negative

^eFP-False positive

^fTN-True negative

^gPPV-Positive predictive value

^hNPV-Negative predictive value