Table 2.
Outcome | Pearson’s r | P value | |
---|---|---|---|
ATP-linked oxygen uptake (substrate) | |||
| |||
Malate-glutamate | −0.487 | 0.040 | |
Succinate | −0.468 | 0.050 | |
α-glycerophosphate | −0.407 | 0.094 | |
| |||
Complex activities | |||
| |||
Complex I | −0.119 | 0.849 | |
Complex IV | −0.222 | 0.720 | |
Complex V | −0.581 | 0.304 | |
| |||
ATP-linked oxygen uptake and related parameters in intact cells | |||
| |||
State 3 | −0.575 | 0.025 | |
State 4 | 0.275 | 0.321 | |
State 3u | −0.276 | 0.340 | |
RCR | −0.584 | 0.022 | |
RCRu | −0.480 | 0.070 | |
SRC | −0.172 | 0.540 | |
| |||
Mitochondrial mass biomarkers | |||
| |||
Citrate synthase | 0.629 | 0.005 | |
mtDNA copy number | 0.030 | 0.915 | |
| |||
mtDNA damage (%) | |||
| |||
Deletions in CYTB | −0.250 | 0.333 | |
Deletions in ND4 | −0.265 | 0.304 |
Correlation parameters were obtained plotting individual values for CGG repeats and mitochondrial outcomes for 12 control and 5 premutation cell lines. Bolded p values represent the presence of a statistically significant correlation between CGG repeats and a given mitochondrial outcome.