Table 2.
Correlation parameters between CGG repeats and mitochondrial outcomes in fibroblasts from control and premutation
| Outcome | Pearson’s r | P value | |
|---|---|---|---|
| ATP-linked oxygen uptake (substrate) | |||
|
| |||
| Malate-glutamate | −0.487 | 0.040 | |
| Succinate | −0.468 | 0.050 | |
| α-glycerophosphate | −0.407 | 0.094 | |
|
| |||
| Complex activities | |||
|
| |||
| Complex I | −0.119 | 0.849 | |
| Complex IV | −0.222 | 0.720 | |
| Complex V | −0.581 | 0.304 | |
|
| |||
| ATP-linked oxygen uptake and related parameters in intact cells | |||
|
| |||
| State 3 | −0.575 | 0.025 | |
| State 4 | 0.275 | 0.321 | |
| State 3u | −0.276 | 0.340 | |
| RCR | −0.584 | 0.022 | |
| RCRu | −0.480 | 0.070 | |
| SRC | −0.172 | 0.540 | |
|
| |||
| Mitochondrial mass biomarkers | |||
|
| |||
| Citrate synthase | 0.629 | 0.005 | |
| mtDNA copy number | 0.030 | 0.915 | |
|
| |||
| mtDNA damage (%) | |||
|
| |||
| Deletions in CYTB | −0.250 | 0.333 | |
| Deletions in ND4 | −0.265 | 0.304 | |
Correlation parameters were obtained plotting individual values for CGG repeats and mitochondrial outcomes for 12 control and 5 premutation cell lines. Bolded p values represent the presence of a statistically significant correlation between CGG repeats and a given mitochondrial outcome.