Table 3.
Associations of prenatal oral antibiotic prescriptions with levels of leptin and adiponectin from venous umbilical cord blood at delivery.
| Unadjusted β (95% CI) |
Adjusted β (95% CI) |
||
|---|---|---|---|
| Cord blood leptin, ng/ml | N (%) | ||
| Any during pregnancy (yes vs. no) | 236 (28.1) | 0.06 (−0.94, 1.05) | 0.14 (−0.89, 1.17) |
| 1st trimester* | 109 (13.0) | −0.62 (−1.96, 0.71) | −0.29 (−1.66, 1.07) |
| 2nd trimester** | 77 (10.5) | −0.57 (−2.15, 1.00) | −1.13 (−2.76, 0.50) |
| 3rd trimester*** | 50 (7.7) | 2.05 (0.13, 3.97) | 2.28 (0.38, 4.17) |
| Cord blood adiponectin, mg/ml | N (%) | ||
| Any during pregnancy (yes vs. no) | 250 (28.4) | −0.41 (−1.40, 0.59) | −0.02 (−1.10, 1.06) |
| 1st trimester* | 117 (13.3) | −0.72 (−2.04, 0.60) | −0.65 (−2.08, 0.77) |
| 2nd trimester** | 81 (10.6) | −1.20 (−2.75, 0.35) | −0.59 (−2.30, 1.12) |
| 3rd trimester*** | 52 (7.6) | 1.40 (−0.49, 3.29) | 1.65 (−0.35, 3.64) |
Adjusted for maternal age, pre-pregnancy BMI, parity, race/ethnicity, education, smoking habits, household income, and child sex and gestation length.
*
Among 839 women for leptin analyses and 880 women for adiponectin analyses
**
Among 730 women (for leptin analyses) and 763 women (for adiponectin analyses) who were not prescribed antibiotics in the 1st trimester
***
Among 653 women (for leptin analyses) and 682 women (for adiponectin analyses) who were not prescribed antibiotics in the 1st or 2nd trimester