TABLE 3.
Lung weights and vascular endothelial filtration coefficient (Kf)
| Left lobe wet weight/body weight (µg/g) |
Left lobe wet/dry ratio |
Kf (ml/min/cmH2O/g dry lung wt) |
|
|---|---|---|---|
| Normoxia | 1.22 ± 0.03 n = 8 |
5.22 ± 0.09 n = 8 |
0.0275 ± 0.0024 n = 6 |
|
24-hr hyperoxia |
1.21 ± 0.04 n = 6 |
4.77 ± 0.08 n = 6 |
0.0241 ± 0.0068 n = 6 |
|
48-hr hyperoxia |
1.60 ± 0.08* n = 16 |
5.70 ± 0.15 n = 16 |
0.0860 ± 0.0129* n = 6 |
| 24-hr saline | 1.24 ± 0.04 n = 5 |
4.99 ± 0.15 n = 5 |
0.0324 ± 0.0056 n = 5 |
| 24-hr LPS | 1.79 ± 0.10& n = 6 |
5.14 ± 0.05 n = 6 |
0.0192 ± 0.0021 n = 5 |
| 3-day LPS | 1.45 ± 0.10 n = 4 |
4.86 ± 0.05 n = 4 |
NA |
| 7-day LPS | 1.44 ± 0.06 n = 3 |
5.36 ± 0.11 n = 3 |
NA |
Values are mean ± SEM. n is the number of rats. One-way ANOVA on Ranks followed by Tukey’s range test (p < 0.05) was used to evaluate differences among means of the groups:
*
significantly different from normoxia;
&
different from saline.