TABLE 6.

Reduced (GSH) and oxidized (GSSG) glutathione content of lung homogenate

	GSH (fraction of normoxia)	GSH/GSSG
Normoxia (n = 7)	1.00	20.0 ± 3.5
24-hr hyperoxia (n = 6)	1.17 ± 0.03*	23.6 ± 1.9
24-hr saline (n = 4)	1.04 ± 0.02	12.7 ± 1.1
24-hr LPS (n = 6)	1.26 ± 0.02*&	36.9 ± 7.4&
7-day LPS (n = 3)	1.00 ± 0.01	10.8 ± 1.1

Values are mean ± SEM. n is the number of rats. One-way ANOVA on Ranks followed by Tukey’s range test (p < 0.05) was used to evaluate differences among means of the five groups:

^*significantly different from normoxia;

^&different from saline. GSH concentration for normoxia lungs was 7.81 ± 0.63 (SEM, n = 7) µmol/g dry wt.