Table 8.
Summary of changes in clinically-relevant indices of lung function and HMPAO lung uptake in rats 24 hrs after treatment with hyperoxia, saline, or LPS as compared to normoxia rats
| BR | HR | Pulse Ox |
Thoracic X-ray |
BW | BAL protein |
BAL cell count |
HMPAO Lung uptake |
|
|---|---|---|---|---|---|---|---|---|
| 24-hyperoxia | −10% | NS | NS | NS | +1.9% | NS | NS | +135% |
| 24-hr saline | NS | NS | NS | NS | NS | NS | + 300% | NS |
| 24-hr LPS | +40% | NS | NS | NS | −6.2% | +70% | +3,000% | +188% |
% change from normoxia. NS, not significant