Figure 2. GM-CSF-deficient Csf2^−/− mice pretreated with PC61 exhibited extensive perivascular and periventricular CNS lesions.

Portrayed are representative sections of Csf2^−/− mice afflicted with severe paralytic EAE (Fig. 1), including the cerebellum (A and D), hindbrain (B and E), brainstem (C and F), and spinal cord (G and I and H and J). Mononuclear inflammatory lesions are marked by black arrows. Images were acquired at 25× original magnification (A–C, G, and H) or 100× original magnification (D–F, I, and J).