TABLE 3.

Spontaneous recovery in transgenic 2D2 mice was facilitated by endogenous GM-CSF

Figure	Strain	mAb pretxt	Incidence	Means (±se) maximal scores (overall)	P	Means (±se) maximal scores (d 20–32)	P	% Maximal weight loss (d20–32)	P
3G and H	2D2-FIG	Y13 isotype control	7 of 7	4.3 ± 0.2	ns	4.3 ± 0.2	<0.001	28.8 ± 3.4%	0.027
3G and H	2D2-FIG	Anti-CD25	8 of 8	4.3 ± 0.2	ns	4.3 ± 0.2	<0.001	25.5 ± 1.8%	ns
3G and H	2D2-FIG Csf2−/−	Y13 isotype control	5 of 5	3.2 ± 0.4	*	1.8 ± 0.2	*	14.9 ± 1.9%	*
3G and H	2D2-FIG Csf2−/−	Anti-CD25	6 of 6	3.8 ± 0.3	ns	3.8 ± 0.3	=0.008	24.4 ± 4.2%	ns

These data are portrayed in Fig. 3G and H. 2D2-FIG and 2D2-FIG Csf2^−/− mice were injected with PC61 or Y13 (isotype control) on d −4 and −2. All mAb were injected at a dose of 250 µg/mAb/injection. Mice were immunized on d 0 with 200 µg MOG35–55 in CFA with i.p. injections of Ptx on d 0 and 2. Mice were scored and weighed daily until the end of the experiment on d 32. Shown are the mean cumulative and maximal scores (±sem). Asterisk indicates the control group.