Both naïve and CD3/CD28-activated, purified CD4+ T cells were examined for expression of OR signaling components, including the GNAL, ADCY3, and the CNG ion channel subunit CNGA2 by real-time PCR analysis of RNA expression (A). Additional experiments (B) examined the expression of the cAMP-producing receptors Olfr544, Olfr642, Olfr744, Olfr16, and the Adrb2. Means ± sd represent 3 separate experiments, each using T cells pooled from ≥3 mice.