TABLE 1.

cAMP analog effects on T cell function

Concentration of cBiMPS	% viable	% CD69+a	% of cells proliferatinga	% of IFN-γ-producing cellsa
No drug added	69 ± 11	61 ± 21	48 ± 14	8 ± 3
50 μM cBiMPS	66 ± 9	59 ± 12	46 ± 13	9 ± 2
250 μM cBiMPS	44 ± 10*	29 ± 9*	37 ± 9	8 ± 1
500 μM cBiMPS	19 ± 12*	13 ± 6*	11 ± 4*	2 ± 1*
500 μM cBiMPS + 500 μM Rp-cAMPS	52 ± 9	33 ± 12*	38 ± 14	7 ± 1
Forskolin	8 ± 4*	6 ± 3*	7 ± 3*	1 ± 1*
No CD3/CD28 stimulation	71 ± 14	1 ± 0*	5 ± 2*	0 ± 0*

Groups were compared by 1-way ANOVA using Tukey’s multiple comparison test.

^aOnly viable cells were examined.

^*P < 0.05, group outcome was significantly different compared with the no-drug-added group.