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. 2016 Aug 27;23(3):217–230. doi: 10.1007/s40292-016-0155-2

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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PCSK9-mediated degradation of the LDL receptor. The secreted PCSK9 binds the epidermal growth factor-like repeat A domain of the LDL receptor present on the plasma membrane of hepatocytes. The complex undergoes clathrin-mediated endocytosis and is then escorted to lysosomes for degradation, in contrast to the physiological recycling of the LDL receptor to the plasma membrane, after binding the circulating LDL particle. The therapeutic approaches that inhibit circulating PCSK9 are highlighted in red boxes

Reproduced with permission from Norata et al. [68]