Table 2.
Change over time: A comparison of the data prior to the publication of our 2009 review, afterwards and with all data pooled
| Pre-2009 | Post-2009 | Overall | ||
|---|---|---|---|---|
| No. publications | 17 | 8 | 25 | |
| Animals/paper | 42.5 | 75.1 | 53 | |
| Infarct volume | Effect size (95 % CI) | 37.5 % (30.3–44.7) | 36.15 % (31.8–40.7) | 36.5 % (31.6–41.3) |
| I 2 (%) | 87 | 72 | 82 | |
| # experiments | 39 | 37 | 76 | |
| # animals | 709 | 574 | 1283 | |
| Neurobehavioural outcome | Effect size (95 % CI) | 24.8 % (−8.7–58.3) | 37.1 % (29.7–44.5) | 35.8 % (28.2–43.5) |
| I 2 (%) | 67 | 58 | 58 | |
| # experiments | 4 | 29 | 33 | |
| # animals | 51 | 422 | 473 | |
| Mortality | Odds ratio (95 % CI) | 0.5 (0.04–5.8) | 1.1 (0.5–2.8) | 1.03 (0.5–2.4) |
| I 2 | – | – | – | |
| # experiments | 1 | 9 | 10 | |
| # animals | 26 | 201 | 227 | |
| Median quality (/15) (interquartile range) | 6 (5–7) | 11.5 (9.8–12) | 7.0 (5–7) | |
| Random allocation to group (%) | 5.9 | 87.5 | 32.0 | |
| Blinded induction of ischaemia (%) | 11.8 | 50.0 | 24.0 | |
| Blinded assessment of outcome (%) | 29.4 | 87.5 | 48.0 | |
| Sample size calculation (%) | 0.0 | 37.5 | 12.0 | |
| Statement of potential conflict of interest (%) | 0.0 | 87.5 | 28.0 | |
| Prespecified exclusion of animals (%) | 11.8 | 62.5 | 28.0 | |
| Explanation of exclusions (%) | 11.8 | 62.5 | 28.0 | |