TABLE 3.
Clostridium difficile infection and VNA2-Tcd levels in pig serum treated with adenovirus Ad/VNA2-Tcdc
| Pig no. | Disease severity score | Ad/VNA-Tcd (ng/ml) | Mesocolon edema | Submucosa edema | Lamina propria edema | Neutrophilic colitis | Epithelium | Luminal contents |
|---|---|---|---|---|---|---|---|---|
| 5 | 4 | 160 | +/− | − | +/− | − | Intact | None |
| 9 | 1 | 300 | + | +/− | − | − | Intact | None |
| 12 | 3 | 350 | − | − | − | − | Intact | None |
| 13 | 4 | 1,000 | + | − | − | +/− | Intact | None |
| 6 | 0 | 1,600 | ++ | − | +/− | − | Intact | None |
| 1 | 3 | 30 | NAa | +++ | ++ | ++ | Intact | Necrotic cell debris (+) |
| 2 | 3 | 100 | + | + | ++ | +/− | Intact | None |
| 14 | 10 | 150 | + | +++ | ++ | ++ | Ulcerated | Necrotic cell debris (++) |
| 7b | 9 | 0 | ++ | +/− | ++ | ++ | Intact | None |
| 15b | 11 | 0 | ++ | +++ | ++ | − | Intact | None |
a
NA, not available.
b
These were control pigs that were treated with an unrelated VNA.
c
−, none; +/−, mild to none; +, mild; ++, moderate; +++, severe.