TABLE 3.

Separate generalized logit regression models at all study visits to predict clinical outcome group status^a

Characteristic	Unit increaseb	ORc (95% CI)
		Return to health vs symptoms only	Return to health vs PTLDS
Acute phase, pretreatment
Fibrinogen	443.74 ng/ml	0.96 (0.65–1.44)	0.78 (0.44–1.36)
MIG	383.42 pg/ml	0.91 (0.63–1.31)	0.84 (0.35–2.02)
IP-10	509.06 pg/ml	0.94 (0.67–1.32)	0.85 (0.32–2.28)
CRPd	57,140.56 ng/ml	1.02 (0.68–1.53)	1.57 (0.88–2.78)
Serum amyloid A	3,173.89 ng/ml	1.09 (0.78–1.51)	1.11 (0.68–1.79)
Ferritin	81,533.50 pg/ml	0.86 (0.55–1.34)	0.52 (0.15–1.82)
CCL19	78.81 pg/ml	1.27 (0.87–1.85)	1.36 (0.75–2.48)
Age	1 yr	1.01 (0.97–1.06)	0.97 (0.90–1.03)
Sex	Female to male	1.16 (0.33–4.15)	0.32 (0.03–3.04)
Erythema migrans	Single to disseminated	0.98 (0.28–3.36)	0.30 (0.03–3.45)
Serology	Negative to positive	1.12 (0.26–4.79)	0.82 (0.12–5.67)
Posttreatment follow-up
CCL19	49.96 pg/ml	1.49 (0.89–2.48)	2.09 (1.12–3.88)e
Age	1 year	1.02 (0.98–1.06)	0.98 (0.92–1.04)
Sex	Female to male	0.96 (0.31–3.03)	0.41 (0.06–2.97)
Presence of EM lesions	Single to disseminated	0.85 (0.27–2.66)	0.10 (0.01–1.96)
Serology	Negative to positive	1.32 (0.38–4.60)	0.72 (0.13–4.05)
1-mo follow-up
CCL19	51.73 pg/ml	1.47 (0.88–2.47)	1.90 (1.06–3.39)e
Age	1 year	1.01 (0.97–1.05)	0.96 (0.90–1.02)
Sex	Female to male	1.05 (0.32–3.40)	0.33 (0.05–2.26)
Presence of EM lesions	Single to disseminated	0.86 (0.27–2.69)	0.09 (0.01–2.33)
Serology	Negative to positive	1.23 (0.33–4.60)	0.48 (0.08–2.72)
3-mo follow-up
CCL19	42.08 pg/ml	1.20 (0.81–1.78)	1.72 (1.03–2.88)e
Age	1 year	1.02 (0.98–1.06)	0.98 (0.92–1.04)
Sex	Female to male	1.07 (0.34–3.44)	0.46 (0.06–3.43)
Presence of EM lesions	Single to disseminated	0.89 (0.29–2.74)	0.18 (0.01–2.24)
Serology	Negative to positive	1.12 (0.32–3.87)	0.52 (0.09–2.92)
6 mo posttreatment
CCL19	30.99 pg/ml	1.17 (0.82–1.67)	1.84 (1.12–3.02)e
Age	1 year	1.02 (0.98–1.06)	0.97 (0.91–1.03)
Sex	Female to male	0.90 (0.29–2.75)	0.26 (0.04–1.92)
Presence of EM lesions	Single to disseminated	0.89 (0.28–2.83)	0.10 (0.01–1.40)
Serology	Negative to positive	1.34 (0.40–4.56)	0.84 (0.15–4.72)
1 yr posttreatment
CCL19	45.97 pg/ml	1.03 (0.56–1.88)	2.83 (1.15–6.94)e
Age	1 year	1.01 (0.97–1.05)	0.98 (0.91–1.04)
Sex	Female to male	0.77 (0.24–2.50)	0.36 (0.04–3.57)
Presence of EM lesions	Single to disseminated	1.07 (0.32–3.52)	0.18 (0.01–2.30)
Serology	Negative to positive	1.35 (0.37–4.97)	1.17 (0.16–8.47)

^aClinical outcome group status (PTLDS, symptoms only, and return to health) was defined using a previously published definition incorporating both persistent symptoms and functional impact (25).

^bFor immune markers, a unit increase was set at 0.5 SD for the Lyme disease participant sample.

^cOR, odds ratio.

^dCRP, C-reactive protein.

^eFor significance of parameter estimate, P ≤ 0.05.