Table 2.
Differential expression of genes related to thioredoxin-related thiol-disulfide enzymes and antioxidant enzymes.
| Gene | Old versus young (fold-difference)a |
Step-up p valueb |
|---|---|---|
| Thiol-disulfide enzymes: thioredoxin-related | ||
| Prxd1 | 0.62 | |
| Prdx2 | 0.35 | |
| Prdx3 | Up 1.4-fold | 0.0074 |
| Prdx4 | 0.20 | |
| Prdx5 | 0.29 | |
| Prdx6 | 0.40 | |
| Prdx6b | 0.93 | |
| Srxn1 | 0.64 | |
| Txn1 | 0.77 | |
| Txn2 | 0.79 | |
| Txnrd1 | 0.65 | |
| Txnrd2 | 0.91 | |
| Txnrd3 | 0.25 | |
| Txndc17 | 0.24 | |
| Txnip | 0.09 | |
|
| ||
| Antioxidant enzymes | ||
| Sod1 | 0.32 | |
| Sod2 | 0.17 | |
| Sod3 | Down 4.1-fold | 0.0074 |
| Cat | 0.75 | |
| G6pd2 | 0.99 | |
aFold-difference in expression in old fibroblasts relative to the expression in young fibroblasts is shown for all genes with a significant difference. Those exceeding the cut-off threshold of 2-fold are shown in bold.
bStep-up false discovery rate for the comparison between young and old cells following correction for multiple comparisons.