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. 2016 Sep 8;6:33094. doi: 10.1038/srep33094

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Copyright © 2016, The Author(s)

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Kaplan-Meier curves show the proportion of children that remained free of malaria episodes over time for IgG subclass responses against PfRH5 and PfRipr (A) IgG1 to PfRH5; (B) IgG3 to PfRH5; (C) IgG1 to PfRipr; (D) IgG3 to PfRH5. Antibody responses were divided into 3 equal response groups: high (green line), medium (red line), and low (blue line) antibody reactivity. Unadjusted data are shown. Wilcoxon log rank tests were carried out: (A) p = 0.004; (B) p < 0.001; (C) p < 0.001; (D) p < 0.001 Symptomatic P. falciparum infection was defined as fever (>37 °C) plus a parasite load of 5000 parasites/μl.