Table 1. Demographics of AMD patients and healthy controls (HCs) used for validation.
| Variables | 1st validation |
2nd validation |
||||||
|---|---|---|---|---|---|---|---|---|
| HC(n = 61) | Early AMD(n = 41) | ExudativeAMD (n = 58) | P value (AMD vs. HC)* | HC(n = 29) | Early AMD(n = 8) | ExudativeAMD (n = 29) | P value (AMD vs. HC)* | |
| Age (years) | 75.7 ± 4.7 | 71.5 ± 6.0 | 72.2 ± 7.0 | <0.001 | 77.0 ± 6.4 | 73.6 ± 7.2 | 72.1 ± 11.0 | 0.108 |
| Gender (M:F) | 20:41 | 12:29 | 23:35 | 0.740 | 14:15 | 0:8 | 6:23 | <0.001 |
| Systemic risk factors | ||||||||
| Smoking (current or ex-smoker, %) | 11† (19.6) | 7 (17.1) | 19 (32.8) | 0.353 | 11† (40.7) | 0 | 6 (20.7) | 0.048 |
| Diabetes (%) | 13 (21.3) | 15 (36.6) | 6 (10.3) | 0.988 | 5† (18.5) | 2 (25) | 5 (17.2) | 0.821 |
| Hypertension (%) | 26 (42.6) | 21 (51.2) | 33 (56.9) | 0.143 | 19† (70.4) | 5 (62.5) | 15 (51.7) | 0.376 |
| Hyperlipidaemia (%) | 17 (27.9) | 9 (22.0) | 17 (29.3) | 0.824 | 2† (33.3) | 3 (37.5) | 9 (31.0) | 1.0 |
| Cardio- or cerebrovascular accident (%) | 8 (13.1) | 1 (2.4) | 2(3.4) | 0.022 | 1† (3.7) | 1 (12.5) | 7 (24.1) | 0.063 |
| Cancer history (%) | 1 (1.6) | 3 (7.3) | 2 (3.4) | 0.409 | 2 (8.3) | 1 (12.5) | 0 | 0.160 |
| Genetic factors (SNP) | ||||||||
| ARMS2 (rs10490924), G/G:G/T or T/T | 24:29 | 11:30 | 4:54 | <0.001 | N/A | 1:7 | 5:22 | 1.0 |
| CFH (rs1061170), A/A:G/A | 46:7 | 34:7 | 44:14 | 0.225 | N/A | 7:1 | 18:7 | 0.643 |
| CFH (rs800292), A/A:A/G or G/G | 10:43 | 3:38 | 10:48 | <0.001 | N/A | 1:6 | 2:25 | 0.511 |
N/A = not available.
Boldface text indicates statistical significance.
*Independent t test, χ2 test, or Fisher’s exact test were used where appropriate.
†Values were missing for some patients.