Table 3. Multivariate regression analysis for identification of clinical or SNP data associated with plasma levels of identified biomarkers.
| Variables | PLTP |
MASP-1 |
||
|---|---|---|---|---|
| Regressioncoefficient | P value | Regressioncoefficient | P value | |
| Age | 0.001 | 0.630 | 0.037 | 0.032 |
| Sex | −0.016 | 0.409 | 0.183 | 0.556 |
| AMD vs. control | 0.166 | <0.001 | 1.251 | <0.001 |
| Smoking | −0.009 | 0.572 | −0.072 | 0.783 |
| ARMS2 (rs10490924) | −0.010 | 0.523 | 0.132 | 0.607 |
| CFH (rs1061170) | 0.016 | 0.344 | 0.212 | 0.443 |
| CFH (rs800292) | −0.045 | 0.019 | 0.078 | 0.795 |
AMD = age-related macular degeneration; ARMS2 = age-related maculopathy susceptibility 2; CFH = complement factor H; MASP-1 = mannan-binding lectin serine protease 1; PLTP = phospholipid transfer protein; SNP, single nucleotide polymorphism.
Bonferroni correction was used to set significance level (0.05/14 = 0.0036). Boldface text indicates statistical significance.