Table 1. Permeability Coefficients (×10⁻⁶ cm/s, mean ± s.e).

Antibiotic	pH 5	pH 6	pH 7	Literature Values of Apparent Octanol Partition Coefficients (log Kapp, mean ± s.d)
Enrofloxacin	8.8 ± 0.1	68 ± 3	124 ± 4	3.48 ± 0.04 (pH 7)32
Pefloxacin	4.11 ± 0.05	10.8 ± 0.2	52 ± 2	0.23 ± 0.05 (pH 7)33
Fleroxacin	4.1 ± 0.2	6.5 ± 0.1	11.0 ± 0.2	−0.72 ± 0.18 (pH 7.4)34
Norfloxacin	0.1	0.122 ± 0.004	0.59 ± 0.02	−1.00 ± 0.03 (pH 7)33