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. 2016 Sep 8;6:32841. doi: 10.1038/srep32841

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(A) Representative images of orthogonal distribution of pH at each region. (B) Spatial pH profiles (top-to-bottom) at each region. This figure indicates that the periphery of the microcolony structure can be more effectively neutralized by the pH 7.0 buffer (vs center or mid-center region). Asterisk (P < 0.05) and double asterisk (P < 0.01) indicate that the values for the different experimental groups are significantly different from each other.