Table 1. tRNAs significant after permutation test.
| Overall Survival |
Recurrence Free Survival |
||||
|---|---|---|---|---|---|
| tRNA ID | Univariate Cox p-value | Permuted p-value | tRNA ID | Univariate Cox p-value | Permuted p-value |
| Chr6.tRNA166-AlaAGC | 0.02 | 0.04 | Chr6.tRNA166-AlaAGC | 0.03 | 0.03 |
| Chr17.tRNA10-GlyTCC | 0.04 | 0.05 | Chr1.tRNA80-GluCTC | 0.05 | 0.04 |
| Chr6.tRNA147-SerAGA | 0.04 | 0.06 | Chr1.tRNA77-GluCTC | 0.05 | 0.04 |
| Chr6.tRNA145-SerAGA | 0.04 | 0.06 | Chr6.tRNA87-GluCTC | 0.07 | 0.06 |
| Chr6.tRNA5-SerAGA | 0.06 | 0.07 | Chr1.tRNA74-GluCTC | 0.07 | 0.06 |
| Chr16.tRNA2-ArgCCT | 0.04 | 0.08 | Chr1.tRNA71-GluCTC | 0.07 | 0.06 |
| Chr6.tRNA50-SerAGA | 0.07 | 0.09 | Chr1.tRNA59-GluCTC | 0.08 | 0.06 |
| Chr12.tRNA8-AlaTGC | 0.08 | 0.09 | Chr6.tRNA77-GluCTC | 0.08 | 0.07 |
| Chr6.tRNA148-SerTGA | 0.07 | 0.09 | Chr1.tRNA118-HisGTG | 0.1 | 0.08 |
| Chr6.tRNA172-SerTGA | 0.07 | 0.09 | Chr6.tRNA152-ValCAC | 0.13 | 0.08 |
| Chr6.tRNA143-LysTTT | 0.06 | 0.09 | Chr1.tRNA116-GluCTC | 0.11 | 0.09 |
| Chr14.tRNA2-LeuTAG | 0.07 | 0.09 | Chr2.tRNA19-GlyGCC | 0.12 | 0.09 |
| Chr6.tRNA51-SerTGA | 0.08 | 0.09 | Chr6.tRNA128-GlyGCC | 0.11 | 0.09 |
| Chr9.tRNA4-ArgTCT | 0.06 | 0.10 | Chr1.tRNA133-GlyCCC | 0.12 | 0.09 |
Two approaches were adopted to select the set of tRNAs for survival analysis. In the CC approach and CO approach, 76 DE tRNAs and 216 tRNAs (retained after filtering for read counts) were selected for Univariate Cox proportional hazards regression model, followed by permutation test. Left panel of the table includes OS significant tRNAs (permuted p-value ≤ 0.1) from both the approaches (n = 3 in CC and n = 14 in CO). The CO approach also included the tRNAs that were significant in the CC approach, which are indicated in bold. Right panel of the table includes tRNAs significant for RFS in CO approach. None of the tRNAs were identified as associated with RFS from the CC approach.