Table 3. Univariate and Multivariate results for Recurrence Free Survival: Case-only approach (Discovery cohort).
| Parameter | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Risk score | 1.89 (1.13–3.19) | 0.02 | 1.86 (1.10–3.13) | 0.02 |
| Tumor stage | 0.38 (0.20–0.71) | 0.003 | 0.39 (0.21–0.73) | 0.003 |
| Tumor grade | 1.58 (0.92–2.74) | 0.10 | ||
| Age at diagnosis | 1.02 (0.99–1.05) | 0.21 | ||
| TNBC status | 0.84 (0.45–1.55) | 0.58 | ||
HR = Hazard Ratio; CI = Confidence Interval; TNBC = Triple Negative Breast Cancer.
Risk scores were constructed from the 14 tRNAs that were significant for RFS in the CO approach. Patients were dichotomized into low and high risk groups based on ROC estimated cut-off point. Univariate Cox analysis was run for risk score and other clinical variables (included in the table). Risk score was further adjusted for potential confounders and was found to be significant (p < 0.05). Patients belonging to high-risk group were associated with poorer RFS (HR > 1).