Table 5. Gene ontology classification for the piRNA targets.
| Gene ontology classification | mRNA targets | piRNAs regulating mRNA target expression |
|---|---|---|
| Regulation of angiogenesis | SEMA3E, TNFSF12, ANGPTL4, CD34 | hsa_piR_000794, hsa_piR_017716, hsa_piR_020829 |
| Apoptotic nuclear changes | ACVR1C | hsa_piR_017716 |
| Fat cell differentiation | SLC2A4, CLIP3, WNT5B | hsa_piR-000794, hsa_piR_020485, hsa_piR_017716, hsa_piR_020829 |
| Regulation of Wnt signaling pathway | TNKS, APCDD1, RSPO1, WNT5B | hsa_piR_000291, hsa_piR_000765, hsa_piR_017716, hsa_piR_020829 |
| Doxorubicin and Daunorubicin metabolic process | AKR1C1 | hsa_piR_020485 |
| Negative regulation of intracellular estrogen receptor signaling pathway | ZNF366 | hsa_piR_000794 |
| Progesterone metabolic process | AKR1C1 | hsa_piR_020485 |
| Hematopoietic stem cell proliferation | CD34 | hsa_piR_020829 |
Representative gene ontology terms with enrichment score > 1.3 and p-value < 0.05 are listed. Each row in columns two and three represent the mRNA targets involved in the functions and the corresponding piRNAs predicted to bind to these targets.