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. 2016 Sep 8;6:32885. doi: 10.1038/srep32885

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Copyright © 2016, The Author(s)

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(A) The oxygen consumption rate (OCR) was greater for control-silenced than ARSB-silenced HepG2 cells at all time points. Values for rotenone- and AMA-treated cells were virtually undetectable at all time pints, with no effect of ARSB silencing discernible. In contrast, ARSB- silencing reduced the OCR at all time points compared to the untreated control. The ARSB-silenced with FCCP-treatment values were greater than the FCCP-alone values. This suggested that ARSB-silencing also had an impact on the electron transport chain and the proton gradient (n = 6). (B) The values for the slopes from 0 to 60 min were significantly different for the untreated ARSB-silenced HepG2 cells and the control-silenced cells, and for the FCCP-exposed ARSB-silenced and control-silenced cells. [AMA = antimycin A; ARSB = arylsulfatase B; ECAR = extracellular acidification rate; FCCP = carbonyl cyanide-p-trifluoromethoxyphenylhydrazone; N.D. = no difference; OCR = oxygen consumption rate; RT = rotenone; UT = untreated].