Level of (A) IGF-1, (B) IL-1β, (C) NF-κB and (D) TNF-α activation in the hippocampus (mean ± SEM) for Ringer's or kainic acid injected rats fed the control, blueberry or piroxicam diet for 8 weeks prior to micro-infusion. A significant group effect was seen for IGF-1 [F(5,21) = 9.57, P < 0.001], IL-1β [F(5,21) = 13.24, P < 0.001], NF-κB [F(5,21) = 11.60, P < 0.001], and TNF-α [F(5,21) = 34.81, P < 0.001]. Post-hoc testing showed a significant difference (aP < 0.05) between the kainic acid injected and the matched diet Ringer's group, a significant difference (bP < 0.05) from the control diet-Ringer's group, and a significant difference (cP < 0.05) from the control diet-kainic acid group