Fig. 1.

Increased morbidity/mortality in JHMV-infected miR-155 ^−/− mice was associated with elevated viral titers within the brain. WT (n = 12) and miR-155 ^−/− mice (n = 12) were infected via i.c. injection with 200 PFU of JHMV. Clinical scores (a) and survival (b) were assessed throughout infection. The increase in both clinical disease and mortality correlated with an impaired ability to control viral replication within the brains at the indicated times p.i. c Statistical significance was determined using Mantel-Cox log-rank test or one-tailed, unpaired, Student’s T tests. Data are representative of at least two independent experiments; ^* p < 0.05; ^** p < 0.01; ^*** p < 0.001