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. 2016 Sep 8;14(1):12. doi: 10.1186/s12953-016-0102-0

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a and b show the comparison of the crystal structures of WT EGFR and the mutant delE746_A750insAP. c and d are the alpha shape models of the drug binding pocket of (a) and (b), respectively. The original site is colored blue while the corresponding mutant site is shown in magenta. The drug molecule (gefitinib) is displayed in purple