Table 2.

Principal clinical features of Fahr’s disease

	Fahr’s disease
	Early onset	Late onset
Cognitive impairment/dementia	A cortical dementia may develop in advanced stages	Usually starts with a subcortical dementia
Psychotic disorders	Organic psychosis (basal ganglia calcification); delusion has syndromic pervasiveness behavioral, is moderately structured and organized, has low emotional participation, varied content. Abnormalities of perception are rare.	Organic psychosis (dementia): delusion is poorly structured and organized, override the contents of jealousy, poisoning, and persecution. Abnormalities of perception are frequent.
Mood disorders	May be associated to psychotic symptoms. Depressive disorders are prevalent towards maniacal ones.	Always associated with cognitive impairment, may precede symptoms as prodromes. Prevailing depression, irritability, hyper-emotionality, apathy
Anxiety disorders	Possible association between Fahr’s disease and obsessive-compulsive disorder.	Possible association between Fahr’s disease and obsessive-compulsive disorder. They can also be associated to cognitive impairment
Other neuro psychiatric/cognitive disorders	Possible attention’s disorders.	Progressive alteration of cognitive functions (attention, language, memory, constructive abilities, etc.)
Extrapyramidal movement disorders	In advanced stages of the disease.	May be present since the onset.
Response to therapy	Poor sensibility to neuroleptic treatment; high susceptibility to side effects.	Poor response to any type of symptomatic therapy. Frequent side effects.