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Schematic outlining potential pathophysiological aspects of OSA, disease mechanisms, and development of associated CVD. Ion channel remodeling may be an important mechanism in associated CVD increasing the propensity for SCD directly and indirectly. Modified from Somers et al, Circulation, 10 with permission from Wolters Kluwer. CVD indicates cardiovascular diseases; OSA, obstructive sleep apnea; SCD, sudden cardiac death; VF, ventricular fibrillation; VT, ventricular tachycardia.
