. 2016 Sep 7;18(1):201. doi: 10.1186/s13075-016-1100-4

Table 1.

Descriptive data of the pre-symptomatic individuals, patients with RA and controls

	Pre-symptomatic individuals^a (n = 251)	RA patients (n = 192)	Controls (n = 198)
Female sex, n (%)	193 (76.9)	144 (75.0)	167 (84.3)
Age, mean ± SD years	50.5 (11.9)^b	56.5 (11.3)	49.3 (14.8)
Ever smoker, n (%)	160/250 (64.0)	129 (67.2)	89/181 (49.2)
HLA-DRB1 SE positive^c, n (%)	166/250 (66.4)	122/192 (63.5)	61/171 (35.7)
PTPN22 1858 T carrier, n (%)	86/250 (34.4)	63 (32.8)	32/173 (18.5)

^aPre-symptomatic individuals were defined as individuals before the onset of symptom of RA

^bMean age, as calculated for all samples when collected, pre-symptomatic individuals: n = 422

^c HLA-DRB1 shared epitope (SE) alleles were defined as 0101/0401/0404/0405/0408

RA rheumatoid arthritis, SD standard deviation