Table 2.
Differentially expressed homeobox genes and other transcription factors
| Gene id | Annotation | Adjusted p-value | CCC | Overall side trend | Tmax relative to T = 0a (Hours) | Side of max change/Fold change(Log2) | Fold change (Log2) |
|---|---|---|---|---|---|---|---|
| Homeobox genes | |||||||
| v1g184843 | Retinal homeobox protein rx-like | 0.000375 | −0.43 | Oral | Hour 72 | Physa | 2.95 |
| v1g127828 | Homeobox protein nkx-(Nk2.2-like) | 0.000189 | −0.24 | physa | Hour 72 | Physa | 2.43 |
| v1g208035 | NK-4 homeobox protein (NvNK-4) | 0.000174 | −0.14 | physa | Hour 8 | Physa | 1.74 |
| v1g130873 | Homeobox protein six3 (NvSix3/6) | 1.58E-06 | −0.12 | physa | Hour 72 | Physa | 2.01 |
| v1g213735 | NvOtxC | 8.12E-11 | −0.08 | physa | Hour 72 | Physa | 4.72 |
| v1g128302 | MoxB (NvMox2) | 8.11E-07 | −0.07 | Oral | Hour 72 | Oral | 5.73 |
| v1g128296 | Homeobox protein mox-2-like (NvMoxD) | 4.21E-11 | 0 | Oral | Hour 72 | Oral | 6.85 |
| v1g128275 | Homeobox protein mox-1-like (NvMoxA) | 2.02E-07 | 0.01 | Oral | Hour 72 | Oral | 4.41 |
| v1g128289 | Homeobox protein mox-1 (NvMoxC) | 1.36E-14 | 0.07 | Oral | Hour 24 | Oral | 6.65 |
| v1g79707 | Diencephalon mesencephalon homeobox protein 1 | 4.7E-10 | 0.11 | Oral | Hour 24 | Oral | 4.28 |
| Other transcription factors | |||||||
| v1g28237 | Transcription factor sp5 | 7.14E-07 | −0.17 | Oral | Hour 24 | Oral | 2.98 |
| v1g200081 | t-box transcription factor tbx15 | 1.64E-05 | −0.05 | Oral | Hour 72 | Oral | 4.03 |
| v1g187332 | Forkhead box protein b1 (NvFoxB) | 4.09E-07 | −0.03 | Oral | Hour 72 | Oral | 2.97 |
| v1g165603 | Forkhead domain protein D1 (NvFoxD1) | 0.02904 | −0.03 | physa | Hour 72 | Oral | 3.54 |
| v1g67043 | Forkhead box protein l2 | 0.0325 | −0.01 | physa | Hour 8 | Physa | 1.86 |
| v1g88753 | t-box transcription factor tbx18 | 0.03405 | 0 | Oral | Hour 72 | Oral | 3.99 |
| v1g235967 | Transcription factor sox-14 (NvSox1) | 3.13E-06 | 0.11 | Oral | Hour 72 | Oral | 2.22 |
| v1g211452 | ets translocation variant 5 isoform 1 | 0.03352 | 0.2 | Oral | Hour 24 | Oral | 1.94 |
| v1g161959 | Hypoxia-inducible factor 1-alpha isoform 2 | 0.04308 | 0.2 | physa | Hour 72 | Physa | 1.19 |
| v1g101900 | Transcription factor sp5 | 3.11E-05 | 0.2 | physa | Hour 72 | Physa | 2.09 |
Genes with low CCC values were sorted by their adjusted time-effect p-value. The column “overall side trend” indicates the side with an overall higher level of expression during regeneration. The next columns show the hour of highest change in expression level as compared to hour 0 (Tmax relative to T = 0), the side in which it is observed (Side of max change), and the level of change in expression (Fold change (Log2)). The other columns contain the hour of overall largest change during regeneration (Time interval of max change) and the side (Side of Max change) and level (Fold change (Log2)) of this change
aHour of maximal change relative to time 0