Table 6.

Polygenic Analysis: TAA‐Associated SNPs Tested for Association With IA Case‐Control Status

Threshold (P)a	SNPs (n)b	P Valuec	Direction of Effect
5×10−8	1	0.245	+
1×10−7	1	0.245	+
1×10−6	1	0.245	+
1×10−5	25	0.0957	−
1×10−4	148	0.658	−
1×10−3	1347	0.741	−
0.01	10 030	0.547	+
0.05	39 150	0.72	+
0.1	67 783	0.693	+
0.2	114 079	0.554	+
0.3	151 575	0.538	+
0.4	183 611	0.651	+
0.5	210 876	0.675	+
10−4 to 10−3	1199	0.588	−
10−3 to 0.01	8683	0.592	+
0.01 to 0.05	29 120	0.965	+
0.05 to 0.1	28 633	0.813	+
0.1 to 0.2	46 296	0.487	+
0.2 to 0.3	37 496	0.761	+
0.3 to 0.4	32 036	0.409	+
0.4 to 0.5	27 265	0.84	+

AAA indicates abdominal aortic aneurysm; IA, intracranial aneurysm; SNPs, single‐nucleotide polymorphisms; TAA, thoracic aortic aneurysm.

^a P value threshold for inclusion of IA‐, AAA‐, or TAA‐associated SNPs in each polygenic model.

^bNumber of SNPs included in each polygenic model.

^c P value for association of the polygenic model with IA, AAA or TAA case‐control status.