Table 6.
Threshold (P)a | SNPs (n)b | P Valuec | Direction of Effect |
---|---|---|---|
5×10−8 | 1 | 0.245 | + |
1×10−7 | 1 | 0.245 | + |
1×10−6 | 1 | 0.245 | + |
1×10−5 | 25 | 0.0957 | − |
1×10−4 | 148 | 0.658 | − |
1×10−3 | 1347 | 0.741 | − |
0.01 | 10 030 | 0.547 | + |
0.05 | 39 150 | 0.72 | + |
0.1 | 67 783 | 0.693 | + |
0.2 | 114 079 | 0.554 | + |
0.3 | 151 575 | 0.538 | + |
0.4 | 183 611 | 0.651 | + |
0.5 | 210 876 | 0.675 | + |
10−4 to 10−3 | 1199 | 0.588 | − |
10−3 to 0.01 | 8683 | 0.592 | + |
0.01 to 0.05 | 29 120 | 0.965 | + |
0.05 to 0.1 | 28 633 | 0.813 | + |
0.1 to 0.2 | 46 296 | 0.487 | + |
0.2 to 0.3 | 37 496 | 0.761 | + |
0.3 to 0.4 | 32 036 | 0.409 | + |
0.4 to 0.5 | 27 265 | 0.84 | + |
AAA indicates abdominal aortic aneurysm; IA, intracranial aneurysm; SNPs, single‐nucleotide polymorphisms; TAA, thoracic aortic aneurysm.
P value threshold for inclusion of IA‐, AAA‐, or TAA‐associated SNPs in each polygenic model.
Number of SNPs included in each polygenic model.
P value for association of the polygenic model with IA, AAA or TAA case‐control status.