Table 11.
SNP—IA | Gene | Chr | RA | AAA | TAA | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
P Value | OR | Dira | P Cochran's Q | P Value | OR | Dira | P Cochran's Q | ||||
rs684158110 | EDNRA | 4 | G | 0.62 | 0.98 | +−−−−+ | 0.45 | 0.43 | 1.07 | NA | NA |
rs1095840912, b | SOX17 | 8 | A | 0.81 | 0.99 | −−++−− | 0.14 | 0.37 | 1.07 | NA | NA |
rs929850612, b | SOX17 | 8 | A | 0.81 | 0.99 | −+−+−− | 0.09 | 0.67 | 0.97 | NA | NA |
rs133304012 | CDKN2BAS | 9 | T | 1.5×10−8 | 1.15 | +++++− | 0.07 | 0.52 | 1.04 | NA | NA |
rs1241340911 | CNNM2 | 10 | G | 0.69 | 1.02 | +−−−++ | 0.70 | 0.95 | 1.01 | NA | NA |
rs931520411 | STARD13‐KL | 13 | T | 0.73 | 1.01 | −−++++ | 0.21 | 0.79 | 1.02 | NA | NA |
rs1166154211 | RBBP8 | 18 | C | 4.1×10−5 | 1.11 | ++++−+ | 0.11 | 0.08 | 1.11 | NA | NA |
SNP—AAA | Gene | Chr | RA | IA | TAA | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
P Value | OR | Dira | P Cochran's Q | P Value | OR | Dira | P Cochran's Q | ||||
rs1075727818 | CDKN2BAS | 9 | G | 5.9×10−17 | 1.30 | +++… | 0.81 | 0.42 | 1.05 | NA | NA |
rs146653513 | LRP1 | 12 | C | 0.95 | 1.00 | −−++−+ | 0.66 | 0.07 | 1.12 | NA | NA |
rs702548614 | DAB2IP | 9 | A | 0.25 | 1.03 | +−++−+ | 0.36 | 0.70 | 0.97 | NA | NA |
rs59983916 | SORT1 | 1 | G | 0.41 | 0.97 | −+−… | 0.76 | 0.42 | 0.94 | NA | NA |
rs651172015 | LDLR | 19 | G | 0.15 | 1.07 | +−+−.. | 0.09 | 0.05 | 1.21 | NA | NA |
SNP—TAA | Gene | Chr | RA | IA | AAA | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
P Value | OR | Dira | P Cochran's Q | P Value | OR | Dira | P Cochran's Q | ||||
rs1051917717, c | FBN1 | 15 | G | 0.99 | 1.00 | ++−−++ | 0.25 | 0.016 | 1.01 | −+++−+ | 0.32 |
rs211818117, c | FBN1 | 15 | G | 0.20 | 0.96 | ++−−−+ | 0.08 | 1.1×10−3 | 1.07 | +−++++ | 0.45 |
Lookup results in different cohorts were combined per subtype, using an inverse‐variance fixed‐effects meta‐analysis. AAA indicates abdominal aortic aneurysm; Chr, chromosome; Dir, direction of effect; IA, intracranial aneurysm; OR, odds ratio; P Cochran's Q, P value from Cochran's Q test; RA, risk allele; SNP, single nucleotide polymorphism; TAA, thoracic aortic aneurysm.
Direction of effect per cohort. For AAA, directions correspond to the cohorts “Iceland,” “Netherlands,” “USA,” “Aneurysm Consortium,” “New Zealand 1,” and “New Zealand 2,” respectively. For IA, directions correspond to the cohorts “Netherlands,” “Finland,” “USA,” “@neurIST,” “Japan 1,” and “Japan 2,” respectively. “+” indicates same direction as previously published aneurysm risk SNP; “−” indicates opposite direction; “.” indicates absence of the SNP in target cohort.
These 2 SNPs are independent (r 2=0.06).
These 2 SNPs are independent (r 2=0.24).