. 2016 Jul 14;5(7):e002603. doi: 10.1161/JAHA.115.002603

Table 11.

Specific Lookup of Previously Published Aneurysm Risk SNPs in 6 Case‐Control Datasets of IA, 6 Case‐Control Data Sets of AAA, and 1 Case‐Control Data Set of TAA

SNP—IA	Gene	Chr	RA	AAA				TAA
SNP—IA	Gene	Chr	RA	P Value	OR	Dir^a	P _{Cochran's Q}	P Value	OR	Dir^a	P _{Cochran's Q}
rs684158110	EDNRA	4	G	0.62	0.98	+−−−−+	0.45	0.43	1.07	NA	NA
rs1095840912, ^b	SOX17	8	A	0.81	0.99	−−++−−	0.14	0.37	1.07	NA	NA
rs929850612, ^b	SOX17	8	A	0.81	0.99	−+−+−−	0.09	0.67	0.97	NA	NA
rs133304012	CDKN2BAS	9	T	1.5×10⁻⁸	1.15	+++++−	0.07	0.52	1.04	NA	NA
rs1241340911	CNNM2	10	G	0.69	1.02	+−−−++	0.70	0.95	1.01	NA	NA
rs931520411	STARD13‐KL	13	T	0.73	1.01	−−++++	0.21	0.79	1.02	NA	NA
rs1166154211	RBBP8	18	C	4.1×10⁻⁵	1.11	++++−+	0.11	0.08	1.11	NA	NA

SNP—AAA	Gene	Chr	RA	IA				TAA
SNP—AAA	Gene	Chr	RA	P Value	OR	Dir^a	P _{Cochran's Q}	P Value	OR	Dir^a	P _{Cochran's Q}
rs1075727818	CDKN2BAS	9	G	5.9×10⁻¹⁷	1.30	+++…	0.81	0.42	1.05	NA	NA
rs146653513	LRP1	12	C	0.95	1.00	−−++−+	0.66	0.07	1.12	NA	NA
rs702548614	DAB2IP	9	A	0.25	1.03	+−++−+	0.36	0.70	0.97	NA	NA
rs59983916	SORT1	1	G	0.41	0.97	−+−…	0.76	0.42	0.94	NA	NA
rs651172015	LDLR	19	G	0.15	1.07	+−+−..	0.09	0.05	1.21	NA	NA

SNP—TAA	Gene	Chr	RA	IA				AAA
SNP—TAA	Gene	Chr	RA	P Value	OR	Dir^a	P _{Cochran's Q}	P Value	OR	Dir^a	P _{Cochran's Q}
rs1051917717, ^c	FBN1	15	G	0.99	1.00	++−−++	0.25	0.016	1.01	−+++−+	0.32
rs211818117, ^c	FBN1	15	G	0.20	0.96	++−−−+	0.08	1.1×10⁻³	1.07	+−++++	0.45

Lookup results in different cohorts were combined per subtype, using an inverse‐variance fixed‐effects meta‐analysis. AAA indicates abdominal aortic aneurysm; Chr, chromosome; Dir, direction of effect; IA, intracranial aneurysm; OR, odds ratio; P _{Cochran's Q}, P value from Cochran's Q test; RA, risk allele; SNP, single nucleotide polymorphism; TAA, thoracic aortic aneurysm.

Direction of effect per cohort. For AAA, directions correspond to the cohorts “Iceland,” “Netherlands,” “USA,” “Aneurysm Consortium,” “New Zealand 1,” and “New Zealand 2,” respectively. For IA, directions correspond to the cohorts “Netherlands,” “Finland,” “USA,” “@neurIST,” “Japan 1,” and “Japan 2,” respectively. “+” indicates same direction as previously published aneurysm risk SNP; “−” indicates opposite direction; “.” indicates absence of the SNP in target cohort.

These 2 SNPs are independent (r ²=0.06).

These 2 SNPs are independent (r ²=0.24).