Table 1.
Cardiovascular Risk Factors in Chinese Adults Ages ≥40 Years With Different Kidney Function Status (REACTION 2011–2012), (N=239 832)
| Variable | Kidney Function (eGFR) | P trend | |||
|---|---|---|---|---|---|
| Normal | Mildly Reduced | CKD | |||
| (≥90) | (75–89) | (60–74) | (<60) | ||
| Men | |||||
| No./% | 59 377/72.20 | 15 834/19.25 | 5215/6.34 | 1820/2.21 | |
| Age, y | 55.9 (48.6–61.7) | 64.5 (57.6–71.0) | 65.4 (59.5–71.5) | 68.1 (61.5–73.4) | <0.0001 |
| High school education or above, % | 39.97 | 44.30 | 44.91 | 40.77 | <0.0001 |
| Current smoker, % | 41.31 | 31.73 | 28.11 | 26.47 | <0.0001 |
| Current drinker, % | 28.33 | 20.51 | 16.60 | 12.93 | <0.0001 |
| Physically active during leisure time, % | 12.7 | 14.9 | 15.7 | 13.9 | <0.0001 |
| BMI, kg/m2 | 24.6 (22.4–26.8) | 24.7 (22.7–26.9) | 25.0 (23.0–27.1) | 24.9 (22.7–27.1) | <0.0001 |
| Waist circumference, cm | 86.5 (80.0–93.0) | 88.0 (81.5–93.8) | 88.0 (82.0–94.0) | 89.0 (82.0–95.0) | <0.0001 |
| SBP, mm Hg | 131 (120–145) | 136 (124–150) | 139 (126–152) | 143 (129–158) | <0.0001 |
| DBP, mm Hg | 80 (73–87) | 80 (72–87) | 80 (73–88) | 80 (73–89) | 0.69 |
| FBG, mmol/L | 5.6 (5.2–6.2) | 5.7 (5.2–6.4) | 5.8 (5.3–6.7) | 5.8 (5.3–6.8) | <0.0001 |
| PBG, mmol/L | 7.0 (5.6–9.3) | 7.7 (6.1–10.5) | 8.0 (6.2–10.9) | 8.6 (6.6–12.2) | <0.0001 |
| HbA1c, % | 5.8 (5.5–6.2) | 5.9 (5.6–6.3) | 5.9 (5.6–6.4) | 6.0 (5.6–6.6) | <0.0001 |
| Total cholesterol, mg/dL | 4.67 (4.00–5.38) | 4.85 (4.22–5.50) | 4.92 (4.26–5.60) | 4.82 (4.17–5.55) | <0.0001 |
| Triglyceride, mg/dL | 1.29 (0.90–1.94) | 1.36 (0.97–2.00) | 1.47 (1.04–2.13) | 1.49 (1.07–2.15) | <0.0001 |
| HDL‐C, mg/dL | 1.20 (1.00–1.45) | 1.21 (1.03–1.43) | 1.20 (1.02–1.40) | 1.16 (0.98–1.37) | 0.74 |
| LDL‐C, mg/dL | 2.68 (2.15–3.24) | 2.83 (2.33–3.37) | 2.90 (2.35–3.46) | 2.84 (2.25–3.39) | <0.0001 |
| HOMA‐IR | 1.51 (0.98–2.31) | 1.68 (1.12–2.55) | 1.90 (1.26–2.86) | 2.05 (1.34–3.18) | <0.0001 |
| Women | |||||
| No./% | 115 690/73.41 | 31 625/20.07 | 7579/4.81 | 2692/1.71 | |
| Age, y | 54.0 (48.0–59.2) | 63.4 (57.4–70.0) | 65.6 (59.3–71.7) | 67.0 (60.2–72.4) | <0.0001 |
| High school education or above, % | 34.83 | 28.66 | 25.41 | 23.60 | <0.0001 |
| Current smoker, % | 1.18 | 1.69 | 2.22 | 2.17 | <0.0001 |
| Current drinker, % | 1.65 | 1.82 | 1.60 | 1.66 | 0.33 |
| Physically active during leisure time, % | 11.8 | 13.4 | 13.0 | 11.9 | <0.0001 |
| BMI, kg/m2 | 24.1 (22.0–26.5) | 24.5 (22.3–26.9) | 24.8 (22.6–27.2) | 24.9 (22.5–27.4) | <0.0001 |
| Waist circumference, cm | 81.7 (76.0–88.0) | 84.0 (78.0–91.0) | 86.0 (79.0–92.0) | 86.8 (80–93.5) | <0.0001 |
| SBP, mm Hg | 127 (115–141) | 135 (121–150) | 137 (124–152) | 140 (125–154) | <0.0001 |
| DBP, mm Hg | 76 (70–83) | 76 (70–84) | 77 (70–85) | 77 (70–85) | <0.0001 |
| FBG, mmol/L | 5.4 (5.1–5.9) | 5.6 (5.2–6.3) | 5.7 (5.3–6.6) | 5.8 (5.3–6.8) | <0.0001 |
| PBG, mmol/L | 7.0 (5.9–8.8) | 7.7 (6.3–10.2) | 8.1 (6.5–11.0) | 8.5 (6.6–12.4) | <0.0001 |
| HbA1c, % | 5.8 (5.5–6.1) | 5.9 (5.6–6.3) | 6.0 (5.7–6.5) | 6.1 (5.7–6.7) | <0.0001 |
| Total cholesterol, mg/dL | 4.88 (4.17–5.61) | 5.27 (4.63–5.96) | 5.34 (4.67–6.05) | 5.28 (4.60–6.06) | <0.0001 |
| Triglyceride, mg/dL | 1.23 (0.89–1.75) | 1.48 (1.08–2.08) | 1.59 (1.15–2.24) | 1.69 (1.20–2.49) | <0.0001 |
| HDL‐C, mg/dL | 1.34 (1.12–1.58) | 1.36 (1.16–1.59) | 1.34 (1.15–1.57) | 1.28 (1.09–1.51) | <0.0001 |
| LDL‐C, mg/dL | 2.78 (2.24–3.37) | 3.06 (2.52–3.63) | 3.09 (2.54–3.67) | 3.00 (2.41–3.63) | <0.0001 |
| HOMA‐IR | 1.69 (1.18–2.44) | 1.93 (1.32–2.88) | 2.14 (1.45–3.22) | 2.31 (1.53–3.72) | <0.0001 |
Data are medians (interquartiles) for continuous variables, or percentages for categorical parameters. BMI indicates body mass index; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FBG, fasting blood glucose; HDL‐C, high‐density lipoprotein cholesterol; HOMA‐IR, homeostasis model assessment‐estimated insulin resistance; LDL‐C, low‐density lipoprotein cholesterol; PBG, postprandial blood glucose; REACTION, Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study; SBP, systolic blood pressure.