. 2016 Jul 22;5(7):e003328. doi: 10.1161/JAHA.116.003328

Table 2.

Association Between Kidney Function and Cardiovascular Risk Factors in Chinese Adults Ages ≥40 Years (REACTION 2011–2012), (N=239 832)

	Normal	Mildly Reduced Kidney Function		CKD	P _trend
	(eGFR ≥90)	(eGFR 75–89)	(eGFR 60–74)	(eGFR <60)	P _trend
Obesity
Men
Age‐adjusted OR (95% CI)	1.00	1.23 (1.17–1.30)^a	1.39 (1.29–1.50)^a	1.34 (1.19–1.51)^a	<0.001
Multivariable‐adjusted OR (95% CI)^b	1.00	1.17 (1.12–1.24)^a	1.26 (1.16–1.37)^a	1.10 (0.96–1.25)	<0.001
Women
Age‐adjusted OR (95% CI)	1.00	0.96 (0.92–0.99)	1.15 (1.05–1.19)^a	1.21 (1.10–1.33)^a	<0.001
Multivariable‐adjusted OR (95% CI)^b	1.00	0.96 (0.92–0.99)	1.07 (1.00–1.14)^a	1.12 (1.01–1.24)^a	0.08
Diabetes mellitus
Men
Age‐adjusted OR (95% CI)	1.00	1.10 (1.05–1.14)^a	1.28 (1.20–1.36)^a	1.74 (1.59–1.91)^a	<0.001
Multivariable‐adjusted OR (95% CI)^c	1.00	1.06 (1.01–1.10)^a	1.12 (1.05–1.19)^a	1.47 (1.34–1.62)^a	<0.001
Women
Age‐adjusted OR (95% CI)	1.00	1.10 (1.07–1.14)^a	1.26 (1.19–1.33)^a	1.69 (1.56–1.83)^a	<0.001
Multivariable‐adjusted OR (95% CI)^c	1.00	1.11 (1.07–1.15)^a	1.22 (1.16–1.29)^a	1.58 (1.45–1.71)^a	<0.001
Hypertension
Men
Age‐adjusted OR (95% CI)	1.00	1.16 (1.12–1.21)^a	1.52 (1.43–1.62)^a	2.15 (1.95–2.38)^a	<0.001
Multivariable‐adjusted OR (95% CI)^d	1.00	1.12 (1.07–1.16)^a	1.42 (1.34–1.52)^a	2.10 (1.88–2.34)^a	<0.001
Women
Age‐adjusted OR (95% CI)	1.00	1.06 (1.03–1.09)^a	1.24 (1.18–1.31)^a	1.61 (1.48–1.75)^a	<0.001
Multivariable‐adjusted OR (95% CI)^d	1.00	1.07 (1.04–1.11)^a	1.22 (1.16–1.29)^a	1.56 (1.43–1.70)^a	<0.001
Dyslipidemia
Men
Age‐adjusted OR (95% CI)	1.00	1.08 (1.04–1.12)^a	1.35 (1.27–1.43)^a	1.67 (1.53–1.82)^a	<0.001
Multivariable‐adjusted OR (95% CI)^e	1.00	0.97 (0.93–1.01)	1.16 (1.09–1.23)^a	1.43 (1.30–1.58)^a	<0.001
Women
Age‐adjusted OR (95% CI)	1.00	1.01 (0.98–1.04)	1.13 (1.07–1.18)^a	1.38 (1.28–1.48)^a	<0.001
Multivariable‐adjusted OR (95% CI)^e	1.00	0.99 (0.96–1.01)	1.06 (1.01–1.12)^a	1.28 (1.18–1.38)^a	<0.001

CKD indicates chronic kidney disease; eGFR, estimated glomerular filtration rate; OR, odds ratio; REACTION, Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study.

Significant data.

Multivariable model adjusted for age, education attainment, current smoking status, current alcohol consumption, metabolic equivalent of task minutes per week (MET‐min/week), hemoglobin A1c (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), and hyperlipidemia (yes/no).

Multivariable model adjusted for age, body mass index (BMI), education attainment, current smoking status, current alcohol consumption, MET‐min/week, SBP, DBP, and hyperlipidemia (yes/no).

Multivariable model adjusted for age, BMI, education attainment, current smoking status, current alcohol consumption, MET‐min/week, HbA1c, and hyperlipidemia (yes/no).

Multivariable model adjusted for age, BMI, education attainment, current smoking status, current alcohol consumption, MET‐min/week, HbA1c, SBP, and DBP.