Figure 2.

Zofenopril effect on NO bioavailability and myocardial p‐eNOS ¹¹⁷⁷, p‐eNOS ⁴⁹⁵, and eNOS expression. VEH indicates vehicle; ZOF, zofenopril. Zofenopril administered at 8 hours (10 mg/kg PO) resulted in significant increase of nitrite levels in both (A) plasma and (B) heart tissue compared with vehicle. C, Immunoblots for p‐eNOS ¹¹⁷⁷, p‐eNOS ⁴⁹⁵, and eNOS with relative optical densitometry (D through F). Results are expressed as mean±SEM. Number inside the circles in the bar denotes the number of animals used per group.