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. 2016 Jul 5;5(7):e003531. doi: 10.1161/JAHA.116.003531

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© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Zofenopril and ramipril effect on a murine model of myocardial ischemia reperfusion (I/R) injury. VEH indicates vehicle; ZOF, zofenopril. A, Murine model of myocardial I/R protocol. B, Area‐at‐risk (AAR) per left ventricle (LV) and infarct (INF) per AAR and LV. Zofenopril administration (10 mg/kg PO) 8 hours before induction of myocardial I/R injury significantly reduced INF/AAR compared with vehicle. There was no difference in AAR/LV between vehicle‐ and zofenopril‐treated animals. C, Circulating cTn‐I levels measured at 4 hours of reperfusion were significantly diminished by zofenopril pretreatment. D, Ramipril administration (3 mg/kg PO) 8 hours before induction of I/R injury significantly reduced the % INF/AAR and % INF/LV. E, cTn‐I release at 4 hours of reperfusion was significantly reduced by ramipril administration compared with vehicle. Results are expressed as mean±SEM. Number in the circle inside the bar denotes the number of animals used per group.