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. 2016 Jun 30;5(7):e003730. doi: 10.1161/JAHA.116.003730

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© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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LIGHT (an acronym for homologous to lymphotoxins, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes, also known as TNFSF14)‐induced interleukin (IL)‐6. Wild‐type mice were infused with recombinant mouse LIGHT for either 5 or 14 days. Plasma was obtained, and the concentration of IL‐6 was determined by ELISA. Data are expressed as mean±SEM; *P<0.05 vs saline‐infused mice; **P<0.01 vs saline‐infused mice. n=6 for WT + LIGHT day 5 and n=8 for WT+saline day 14 and WT+LIGHT day 14.