Figure 5.

LIGHT (an acronym for homologous to lymphotoxins, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes, also known as TNFSF14)‐induced proteinuria and urine osmolality is inhibited by cystamine and is dependent on interleukin (IL)‐6 and endothelial hypoxia inducible factor (HIF)‐1α. Wild‐type (WT) or mutant mice were infused with recombinant mouse LIGHT for up to 14 days in the presence or absence of cystamine (Cys). Twenty‐four‐hour urine specimens were collected at the times indicated, and the ratio of albumin to creatinine (A) and urine osmolality (B) was determined. Data are expressed as mean±SEM; *P<0.05 vs saline‐infused mice; ^# P<0.05 vs LIGHT‐infused mice. n=6 for all groups except for WT+saline day 14, WT+LIGHT day 14, where n=8 (V‐cre indicates VE‐cadherin‐cre ⁺).