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. 2016 Jul 22;5(7):e003872. doi: 10.1161/JAHA.116.003872

Figure 8.

Figure 8

Effects of intravenous administration of Mdivi1‐NP on infarct size in vivo in IR hearts of WT mice, CypD‐KO mice, and cardiac‐specific Bax‐KO mice. A, Effects of Mdivi1 alone (1.2 mg/kg) or Mdivi1‐NP (0.24 and 1.2 mg/kg) on infarct size after intravenous administration at the time of reperfusion in WT mice (N=7–8 per group). Scale bar: 2 mm. B, Effects of Mdivi1‐NP (1.2 mg/kg) on infarct size in CypD‐KO mice (N=7–8 per group). Scale bar: 2 mm. C, Confirmation of deletion of Bax protein expression in cardiac‐specific Bax‐KO mice heart. In the left figure, we compared to control mice heart. In the right figure, we compared with other organs in cardiac‐specific Bax KO mice. D, Effects of Mdivi1‐NP (1.2 mg/kg) on infarct size in cardiac‐specific Bax‐KO mice (left; N=4 per group). The area at risk is shown as a percentage of the left ventricle (N=5 per group). Scale bar: 2 mm. AAR indicates area at risk; Bax, Bcl2‐associated X protein; CS, cardiac‐specific; CsA, cyclosporine A; CypD‐KO, cyclophilin D knockout; IR, ischemia‐reperfusion; Mdivi1, mitochondrial division inhibitor 1; NP, nanoparticles; NS, not significant; WT, wild type.