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Changes of phosphorylation of MYPT‐1 after exposure of HK‐2 cells to ET‐1. A, Time course of MYPT‐1 phosphorylation showed that the ratio of phosphorylated MYPT‐1 to MYPT‐1 increased, as expected, early, ie, after 5 and 30 minutes of exposure of HK‐2 cells to ET‐1. Macitentan effectively prevented such an effect. B, BQ‐788 also prevented the increase in the phosphorylated MYPT‐1/MYPT‐1 ratio induced by ET‐1. Mean values of 3 independent experiments, each in duplicate.
