Table 2.

Proportion of Women With a Change in Originally Planned Therapy by Subgroup

Subgroup	No.	%	Test of Interaction P
All patients	17	14.0
Lines of therapy
Newly metastatic	7	12.5	.72
1 prior line of therapy in metastatic setting	2	9.5
≥ 2 prior lines of therapy in metastatic setting	8	18.2
2 lines (n = 14)	2	14.3
3 lines (n = 8)	1	12.5
4 lines (n = 4)	1	25
5 lines (n = 4)	1	25
≥6 lines (n = 14)	3	21.4
Duration from primary breast cancer diagnosis and biopsy
First quartile (<35 months)	4	11.4	.15
Second quartile (36-67 months)	4	15.4
Third quartile (68-118 months)	7	24.1
Fourth quartile (>118 months)	2	6.5