Table 2.
Bevacizumab, Carboplatin, and Paclitaxel Versus Carboplatin Versus Carboplatin Plus Paclitaxel (control; Fig 3)
| Measure | Score/Result |
|---|---|
| Clinical benefit score (maximum, 180 points) | |
| Improvement ([12.3 − 10.3]/10.3 = 19%) | |
| OS score (1 × 16) | 16 |
| Toxicity score (maximum, 20 points) | |
| Carboplatin plus paclitaxel (control) | 15 (grade 3 to 5) |
| Bevacizumab, carboplatin, and paclitaxel | 22 (grade 3 to 5) |
| Toxicity score ([22 − 15]/15 = 46%) | 0 |
| Bonus points (maximum, 30 points) | |
| Palliation | 0 |
| Treatment-free interval | 0 |
| Total bonus points | 0 |
| Net health benefit (maximum, 130 points) | 16 |
| Drug cost (monthly) | |
| Drug acquisition cost | $11,907.87 |
| Patient copay | Calculated per patient |
Abbreviation: OS, overall survival.