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. 2016 Sep 1;14(7):395–406. doi: 10.1089/adt.2016.730

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© Scott J. Warchal et al., 2016; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Fig. 4. — Heat map of theta values between pairs of cell lines for separate compounds. (A) Difference in theta values calculated between pairs of cell lines treated with 21 compounds at 1 μM concentration. Images show differential response between KPL4 and MCF7 cell lines treated with 1 μM SN38. MCF7 cells are observed to decrease in cell area, with bright staining for the endoplasmic reticulum, whereas the KPL4 cells produce a “fried egg” morphology with large spread cells and weak endoplasmic reticulum staining. Channels used are as follows: Red—MitoTracker DeepRed (mitochondria); Green—Concanavalin A (endoplasmic reticulum); Blue—Hoechst33342 (nuclei). Scale bar: 100 μm. (B) Circular histogram of theta values calculated for MCF7 and KPL4 cells treated with 1 μM SN38.