Table 1. Hepatitis E virus RNA progression in blood donors, Germany, 2011 (n = 10).
| Donor | Maximum concentration (IU/mL) |
Daya with maximum concentration | Maximum concentration in window period (IU/mL) |
Distance to last negative sample (days) | Distance to last positive sample (days) |
Mean time between serial samples in days (range) |
Duration interval 1b (days) | Duration interval 2c (days) |
|---|---|---|---|---|---|---|---|---|
| D1 | 2.63 × 104 | 0 | 5.13 × 103 | 43 | 10 | 5 (3–10) |
20 | (47) |
| D2 | 1.02 × 105 | 25 | 1.02 × 105 | 46 | 26 | 11 (5–26) |
52 | (88) |
| D3 | 1.51 × 103 | 0 | No window period | 30 | 8 | 8 (8) |
1 | 20 |
| D4 | 4.74 × 104 | 28 | 4.74 × 104 | 9 | 6 | 10 (6–15) |
42 | 50 |
| D5 | 1.86 × 101 | 0 | No window period | > 1 year | 3 | 7 (3–11) |
11 | (195) |
| D6 | 1.63 × 104 | 21 | 1.63 × 104 | 7 | 7 | 7 (7) |
35 | 42 |
| D7 | 2.13 × 104 | 33 | 2.13 × 104 | 7 | 3 | 6 (3–12) |
46 | 51 |
| D8 | 2.19 × 105 | 28 | 2.19 × 105 | 28 | 7 | 6 (3–12) |
52 | 80 |
| D9 | 1.36 × 103 | 7 | 1.36 × 103 | 54 | 42 | 16 (3–42) |
7 | (55) |
| D10 | 2.48 × 103 | 21 | 2.48 × 103 | 129 | 38 | 21 (21) |
21 | (105) |
| Range | 1.86 × 101 – 2.19 × 105 | 0–33 | 1.36 × 103 – 2.19 × 105 | NC | NC | NC | 1–52 | 20–80 |
| Mean | 4.38 × 104 | 20 | 5.19 × 104 | NC | NC | NC | 29 | 49 |
| Median | 1.88 × 104 | 23 | 1.88 × 104 | NC | NC | NC | 28 | 50 |
NC: not calculated.
a Day x post detection of HEV RNA by PCR screening.
b Duration interval 1: first positive to last positive sample.
c Duration interval 2: starting at half of the interval between the last negative and the first positive sample and ending at half of the interval between the last positive and the first negative sample. Data in parenthesis were excluded from the calculation of mean and median values because the last hepatitis E virus RNA-negative samples went back more than 30 days.