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. 2016 Sep 1;21(35):30332. doi: 10.2807/1560-7917.ES.2016.21.35.30332

Table 2. Occurrence of anti-hepatitis E virus antibody classes (IgA, IgM and IgG) and first detection and duration of IgM and IgG seropositivity in two serological assays, blood donors, Germany, 2011 (n = 10).

IgA IgM IgG
Mikrogen Wantai Mikrogen Wantai Mikrogen Wantai Mikrogen Mikrogen Wantai Mikrogen Wantai Mikrogen
Donor Mean time between samples
in days (range)		 First positive detection
on day xa 		Durationb and
detection interval
in days (range)		 Maximum concentration
on day xa 		First positive detection
on day xa 		First positive detection
on day xa 		Durationb and
detection interval
in days (range)		 Durationb
and detection interval
in days (range)		 Maximum concentration
on day xa 		Maximum concentration
on day xa 		Maximum concentration (U/mL) First positive detection
on day xa 		First positive detection
on day xa 		Maximum concentration
on day xa 		Maximum concentration
on day xa 		Maximum concentration (U/mL)
D1 6
(3–14)		 8 5
(8)		 8 8 8 > 55
(8 – >61)		 > 55
(8– >61)		 16 16 83.61 13 8 44 44 76.66
D2 17
(7–44)		 35 102
(35 – >132)		 68 35 35 > 54
(35 – >84)		 > 54
(35 – >84)		 42 42 65.55 35 35 132 132 143.9
D3 17
(7–44)		 8 13
(8)		 8 0 0 > 168
(0 – >168)		 > 52
(0 – >52)		 8 8 88.82 8 0 23 30 76.26
D4 11
(3–27)		 42 159
(42 – >194)		 48 42 42 159
(42 – >194)		 80
(42–111)		 48 48 93.62 42 42 111 130 149.39
D5 4
(3–11)		 0 47
(0 – >47)		 11 0 0 > 47
(0 – >47)		 > 47
(0 – >47)		 0 0 96.95 0 0 47 47 96.61
D6 7
(6–8)		 28 130
(28– >154)		 28 28 28 130
(28 – >154)		 130
(28 – >154)		 28 28 123.91 28 28 > 119 > 119 167.64
D7 8
(3–46)		 40 6
(40)		 40 40 40 10
(40–46)		 34
(40 – >49)		 40 40 38.07 49 40 158 158 63.96
D8 7
(3–21)		 ND ND ND 32 28 7
(1)		 23
(28–46)		 32 32 26.23 39 39 52 52 47.74
D9 11
(3–21)		 ND ND ND ND ND ND ND ND ND ND 49 49 132 > 137 56.05
D10 19
(4–38)		 ND ND ND ND ND ND ND ND ND ND 59 59 59 59 65.03
Range NC 8–42 5–159 8–68 8–42 8–42 7–159 23–130 16–48 16–48 26.23–123.9 13–59 8–42 44–158 30–158 47.74–167.64
Meanc NC 31 80 38 31 30 69 63 34 34 71.83 34 32 103 89 108.20
Medianc NC 35 102 40 34 32 55 55 36 36 74.58 37 37 115 86 110.30

NC: not calculated; ND: no detection of antibodies.

a Day x post detection of HEV RNA by PCR screening.

b Duration: starting at half of the interval between the last negative and first positive sample and ending at half of the interval between last positive and first negative sample.

c IgA: donors D3, D5, D8, D9 and D10 were excluded from the calculation of mean and median values. IgM/IgG: donors D3, D5, D9 and D10 were excluded from the calculation of mean and median values. Donors were excluded either because no antibodies were detected (IgA: D8, IgM/IgG: D9 and D10) or because all samples were taken ≥ 30 days from each other (D3 and D5).