Table 1.
Morphological parameters and lipid profiles of 8 weeks treatment of control and HFD-obese rats.
Group I | Group II | Group III | Group IV | |
---|---|---|---|---|
Morphological parameters (g/100 g BW) | ||||
Retroperitoneal fat | 0.60 ± 0.11a | 2.47 ± 0.12c | 0.51 ± 0.06a | 1.43 ± 0.11b |
Periepididymal fat | 0.53 ± 0.09a | 3.28 ± 0.12c | 0.52 ± 0.08a | 1.79 ± 0.11b |
Mesenteric fat | 0.51 ± 0.15a | 2.72 ± 0.05c | 0.46 ± 0.07a | 1.37 ± 0.08b |
Interscapular brown fat | 0.06 ± 0.07a | 0.15 ± 0.04a | 0.06 ± 0.04a | 0.15 ± 0.05a |
Liver | 4.81 ± 0.08c | 2.87 ± 0.05a | 2.81 ± 0.15a | 3.23 ± 0.1b |
Heart | 0.38 ± 0.11a | 0.36 ± 0.05a | 0.35 ± 0.04a | 0.48 ± 0.05a |
Kidney | 1.23 ± 0.02b | 0.96 ± 0.23a | 0.94 ± 0.06a | 1.26 ± 0.14b |
Soleus muscle | 0.03 ± 0.005a | 0.04 ± 0.005a | 0.03 ± 0.03a | 0.03 ± 0.04a |
Gastrocnemius muscle | 0.46 ± 0.11a | 0.43 ± 0.07a | 0.45 ± 0.08a | 0.42 ± 0.05a |
Liver lipid profile (mg/g) | ||||
Triglycerides | 3.9 ± 1a | 6.4 ± 0.41b | 3.8 ± 0.92a | 5.7 ± 0.23b |
Total cholesterol | 1.2 ± 0.56a | 1.6 ± 0.32a | 1.4 ± 0.47a | 1.3 ± 0.72a |
Skeletal muscle lipid profile (mg/g) | ||||
Triglycerides | 4.2 ± 0.45b | 8.4 ± 0.4c | 3.8 ± 0.7ab | 2.8 ± 0.75a |
Total cholesterol | 1.1 ± 0.72a | 1.3 ± 0.2a | 1.2 ± 0.51a | 1.3 ± 0.64a |
Oxidative stress markers | ||||
Serum SOD (% SOD) | 34.3 ± 1.2b | 25.8 ± 2.2a | 41.6 ± 1.9c | 39.4 ± 3.1c |
Serum GSH (μg/ml) | 1220.1 ± 14b | 1130.5 ± 32a | 2430.2 ± 19d | 2192.6 ± 29c |
Serum catalase (unit mg protein) | 112.6 ± 16c | 67.3 ± 4.2a | 93 ± 6.8b | 92.8 ± 5.06b |
Serum TBARS (nmole/ml) | 20.2 ± 1.9b | 22.8 ± 2.3c | 18.6 ± 2.7a | 17.9 ± 4.1a |
Serum NO (μM/ml) | 22.9 ± 2.7a | 35.3 ± 2.1c | 24.8 ± 3.2b | 24.2 ± 1.5b |
Data represent mean ± SEM (n = 6), comparison between group pairs were performed by ANOVA, using Duncana test. Different superscript letters (a,b,c,d) indicate statistical difference (P < 0.05) between the groups.