Table 1.

Baseline characteristics of study patients

Characteristics	n = 499a	n = 41 rejections	n = 431 non-rejection	P-values
Age, years, mean (standard deviation)	50.8 (13.7)	46.1 (13.9)	51.2 (13.5)	0.011
Male sex	393 (79)	34 (83)	338 (78)	0.689
Race
Caucasian	443 (89)	35 (85)	386 (90)	0.427
African American	16 (3)	3 (7)	13 (3)	0.154
Asian	11 (2)	1 (2)	8 (2)	0.562
Hispanic	9 (2)	1 (2)	8 (2)	0.562
Others	20 (4)	1 (2)	16 (4)	1.000
Non-Caucasian	56 (11)	6 (15)	45 (10)	0.427
Indication for cardiac transplantation
Coronary artery disease	185 (37)	16 (37)	160 (37)	0.866
Non-ischaemic cardiomyopathy	256 (51)	22 (54)	228 (53)	1.000
Other indications	38 (8)	3 (7)	43 (10)	0.785
Unknown indication	20 (4)	0 (0)	0 (0)	–
Interval between transplantation and study enrollment
Enrolled prior to transplantation	70 (14)	6 (15)	62 (14)	1.000
<6 months	367 (7)	29 (71)	323 (75)	0.575
6–12 months	24 (5)	2 (5)	15 (3)	0.652
13–36 months	20 (4)	2 (5)	18 (4)	0.689
37–60 months	2 (0)	0 (0)	2 (0)	1.000
>60 months	16 (3)	2 (5)	11 (3)	0.314
Cytomegalovirus serology (IgG) status
Donor and recipient positive	150 (30)	13 (32)	129 (30)	0.859
Donor and recipient negative	78 (16)	5 (12)	68 (16)	0.656
Donor positive and recipient negative	84 (17)	8 (20)	72 (17)	0.663
Donor negative and recipient positive	113 (23)	8 (20)	99 (23)	0.700
Unknown	74 (15)	7 (17)	63 (15)	0.647
Use of ventricular assist device before transplantation	118 (24)	6 (15)	110 (26)	0.133
Induction therapy (any)	384 (77)	34 (83)	295 (68)	0.074
Immunosuppressive therapy, at any time during study
Cyclosporin A	298 (60)	29 (71)	256 (59)	0.183
Tacrolimus	309 (62)	24 (59)	265 (61)	0.739
Mycophenolate mofetil or mycophenolic acid	421 (84)
Prednisone	436 (87)	39 (95)	394 (91)	0.561
Left ventricular ejection fraction at first study visit, mean % (standard deviation)	64.1 (9.6)	63.1 (8.7)	64.7 (9.5)	0.301

Values are n (%) unless indicated otherwise.

IgG, immunoglobulin G.

^aTwenty-seven patients did not have central pathology readings.